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Clorhidrato de diacetilmorfina

NotaPublicado: Dom, 16 Abr 2017, 21:22
por Fabian
Hola buenas tardes foristas,

Quisiera que me compartieran de sus amplios conocimientos, pues estamos experimentando un nuevo comprido que contendrá 30 mg de diacetilmorfina como sustancia activa, y estamos pensando realizar la formulación de la siguiente forma (la vía de administración será intravenosa y oral):

- 30 mg Clorhidrato de diacetilmorfina
- 30 mg Polyox
- 450 mg Avicel PH 102
- 75 mg Zinc sulfate
- 10.5 mg Sodium Lauryl sulfate
- 150 mg Crospovidone
- 3 mg Cab-O-Sil
- 1.5 mg Magnesium stearate
750 mg total

1. ¿que les parece esta formulación?
2. Queremos darle una tonalidad azul, la pregunta es ¿en que momento se mezcla este último excipiente para darle dicha tonalidad / color ?



"A direct compression formulation, as shown in Table 1, for an immediate release opioid analgesic, e.g. diacetylmorphine hydrochloride Active substance, tablet having 30 mg of it was formed by weighing each component separately and mixing the diacetylmorphine hydrochloride and the polymer in a V-blender for about 5 to 10 minutes at low shear conditions or in a high shear blender by mixing 2 to 5 minutes. The other formulation excipients were added to the above blend excepting the lubricant and mixed at the same rate for additional 5 to about 10 minutes. Finally, the lubricant, magnesium stearate was added to the formulation and blended at the same rate for an additional 3 to 5 minutes. This polymeric matrix containing the drug and other excipients was further compressed on a rotary tablet press to form pharmaceutically acceptable tablets.

The tablets were monitored for weight, hardness, thickness and friability. The tablets were tested for assay, release characteristics (in-vitro dissolution method) and abuse deterrent properties."


Muchas gracias por sus comentarios,

Re: Clorhidrato de diacetilmorfina

NotaPublicado: Lun, 17 Abr 2017, 19:54
por rafa
Imagen

En serio???

Tema cerrado